The front USB ports on any computer should never be used for USB Audio devices (regardless of manufacturer) because the wire the comes from the motherboard to the port is not properly shielded and cannot handle the data load requirements for realtime audio.
To resolve this issue, plug your AudioBox (or any USB Audio device you wish to use) into a port on the motherboard which on a desktop is on the back of the system.
Use the front USB ports for connecting cameras, USB Flash drives, etc. If any of those devices start to show connectivity problems, then you should probably discontinue using your front USB ports altogether and use the rear ports.
Please contact PreSonus Technical Support by creating a Support Ticket at My.PreSonus.com for further assistance.